反应详情

(2R)-2-[[(1R)-1-(2-Bromophenyl)ethoxy]methyl]oxirane (1.00 g) obtained in Step 1 was dissolved in acetonitrile (10 ml), palladium acetate (II) (45 mg), tri-o-tolylphosphine (63 mg), triethylamine (0.65 ml) and methyl acrylate (0.42 ml) were added, and the mixture was heated under reflux for 3 hr. The reaction mixture was cooled to room temperature, and, after filtration through celite, concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=5:1) to give the title compound (203 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hr
3. filtrationafter filtration through celite
4. concentrationconcentrated under reduced pressure
5. customThe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=5:1)