Water → 2-[7-(4-Trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylmethyl]-benzonitrile

HRID 118163Notes

Reaction equation

HRID 118163 reaction equation
[Cu:29]([C:30]#[N:31])[C:32]#[N:33].[I:1][c:2]1[c:3]([CH2:4][c:5]2[s:6][c:7]3[n:8][cH:9][n:10][c:11]([NH:14][c:15]4[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]4)[c:12]3[n:13]2)[cH:25][cH:26][cH:27][cH:28]1.[O:34]=[CH:35][N:36]([CH3:37])[CH3:38].[OH2:39]>>[c:2]1([C:30]#[N:31])[c:3]([CH2:4][c:5]2[s:6][c:7]3[n:8][cH:9][n:10][c:11]([NH:14][c:15]4[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]4)[c:12]3[n:13]2)[cH:25][cH:26][cH:27][cH:28]1

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 42622946[2-(2-Iodo-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amineHCID 178418260HCID 178418260, compound

Product 1

HCID 685167402-[7-(4-Trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylmethyl]-benzonitrile

Sources & evidence

ORD record
ord-3f7329760dc74ac59abe1fc87206fc8a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…