反应详情

To a solution of 1-(3,5-dimethoxyphenyl)-1-(hex-1-enyl)-cyclopentane (1 equiv.) in ethyl acetate (0.11M) was added 10% Pd/C (17%, w/w) and the resulting suspension was stirred vigorously under an hydrogen atmosphere, overnight at room temperature. The catalyst was removed by filtration through celite and the filtrate was evaporated under reduced pressure to afford the crude product. Purification through a short column of silica gel using 5% diethyl ether-petroleum ether yielded the title compound in 95% yield.

1. customThe catalyst was removed by filtration through celite
2. customthe filtrate was evaporated under reduced pressure
3. customto afford the crude product
4. customPurification through a short column of silica gel using 5% diethyl ether-petroleum ether