Hydrazine hydrate (1:1) → 6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

HRID 1181677Notes

Reaction equation

HRID 1181677 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[NH:10][C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[CH:6]=1>C(O)C>[NH:2]([C:5]1[NH:10][C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[CH:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 113786296-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

Hydrazine hydrate (12.7 ml) was added to a suspension 6-chloro-3-methyl-2,4(1H,3H)-pyrimidinedione (10 g) in ethanol (190 ml). The mixture was heated at 75° C. for 40 hours, cooled to room temperature. The yellow solid precipitated was filtered and dried give the subtitle compound (8.5 g). Mass: 156.76 (M+H).

Workup

  1. temperaturecooled to room temperature
  2. customThe yellow solid precipitated
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-cb95daa1d14e4dd892fa0c7451e241d7
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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