Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione

HRID 1181682Notes

Reaction equation

HRID 1181682 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 694308686-Chloro-1-isobutylpyrimidine-2,4(1h,3h)-dione

Product 1

HCID 694280776-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (5.9 ml) was added to a solution of 6-chloro-1-isobutylpyrimidine-2,4(1H,3H)-dione synthesized according to procedure described in Heterocycles, 1990, 31(9), 1641-1646, (5.9 g) in ethanol (100 ml). The mixture was heated at reflux for 16 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was crystallized from ethanol to give the subtitle compound (5.8 g).

Workup

  1. customsynthesized
  2. temperatureThe mixture was heated
  3. temperatureat reflux for 16 hours
  4. customevaporated under reduced pressure
  5. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-1f7001115b7e4bd986db5fa5ead6b051
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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