Dichloromethane → 5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 118171Notes

Reaction equation

HRID 118171 reaction equation
[CH3:1][CH:2]1[N:3]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:4][CH2:5][N:6]([c:8]2[c:9]3[c:10]([n:11][cH:12][n:13]2)[nH:14][cH:15][c:16]3[CH3:17])[CH2:7]1.[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][N:6]([c:8]2[c:9]3[c:10]([n:11][cH:12][n:13]2)[nH:14][cH:15][c:16]3[CH3:17])[CH2:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68728212tert-butyl 2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 687285275-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-0d0501d5c0554e4ab968647827889d18
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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