Potassium Carbonate → 2-[(5-Choro-1h-indol-3-yl)methyl]-7-isobutyl-3-(1-methyl-1h-imidazol-2-yl)-5-(2-morpholin-4-ylethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione

HRID 1181762Notes

Reaction equation

HRID 1181762 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([N:15]([CH2:29][CH:30]([CH3:32])[CH3:31])[C:16](=[O:28])[NH:17][C:18]2=[O:27])=[N:13]1.Cl[CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([N:15]([CH2:29][CH:30]([CH3:32])[CH3:31])[C:16](=[O:28])[N:17]([CH2:34][CH2:35][N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)[C:18]2=[O:27])=[N:13]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 767274-(2-Chloroethyl)morpholineHCID 589809452-[(5-chloro-1H-indol-3-yl)methyl]-7-isobutyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Product 1

HCID 589809532-[(5-Choro-1h-indol-3-yl)methyl]-7-isobutyl-3-(1-methyl-1h-imidazol-2-yl)-5-(2-morpholin-4-ylethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione

Procedure

This compound was synthesized by the reaction of 2-[(5-chloro-1H-indol-3-yl)methyl]-7-isobutyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and 4-(2-chloroethyl)morpholine using potassium carbonate as a base. Mass: 565.17 (M+H).

Sources & evidence

ORD record
ord-60db4d491400446a80d47ab8326bbb72
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

Loading…