1-Methyl-2-imidazolecarboxaldehyde → 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181766Notes

Reaction equation

HRID 1181766 reaction equation
[NH:1]([C:3]1[NH:8][C:7](=[O:9])[N:6]([CH3:10])[C:5](=[O:11])[CH:4]=1)[NH2:2].[Cl:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]=[C:16]2[CH:22]=O.[CH3:24][N:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH:30]=O>>[Cl:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]=[C:16]2[CH2:22][N:2]1[C:30]([C:26]2[N:25]([CH3:24])[CH:29]=[CH:28][N:27]=2)=[C:4]2[C:3]([NH:8][C:7](=[O:9])[N:6]([CH3:10])[C:5]2=[O:11])=[N:1]1

Participants

4

Reactant 3

HCID 1395751-Methyl-2-imidazolecarboxaldehydeHCID 27953745-chloro-1H-indole-3-carbaldehydeHCID 113786296-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 1363341142-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Procedure

This compound was made following the procedure described above, starting with 6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first with 5-chloro-1H-indole-3-carbaldehyde, followed by 1-methyl-1H-imidazole-2-carbaldehyde

Sources & evidence

ORD record
ord-b979ddfa963446599daff7ea298a6a37
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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