Acetyl chloride → N-{2-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-imidazol-4-yl}acetamide

HRID 1181781Notes

Reaction equation

HRID 1181781 reaction equation
Cl.[NH2:2][C:3]1[N:4]=[C:5]([C:9]2[N:10]([CH2:25][C:26]3[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=4[S:28][CH:27]=3)[N:11]=[C:12]3[C:17]=2[C:16](=[O:18])[N:15]([CH3:19])[C:14](=[O:20])[N:13]3[CH2:21][CH:22]([CH3:24])[CH3:23])[N:6]([CH3:8])[CH:7]=1.[C:35](Cl)(=[O:37])[CH3:36]>C(N(CC)CC)C>[S:28]1[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:26]([CH2:25][N:10]2[C:9]([C:5]3[N:6]([CH3:8])[CH:7]=[C:3]([NH:2][C:35](=[O:37])[CH3:36])[N:4]=3)=[C:17]3[C:12]([N:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:14](=[O:20])[N:15]([CH3:19])[C:16]3=[O:18])=[N:11]2)=[CH:27]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 694290173-(4-amino-1-methyl-1H-imidazol-2-yl)-2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione hydrochloride

Product 1

HCID 58981144N-{2-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-imidazol-4-yl}acetamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was synthesized by the reaction of 3-(4-amino-1-methyl-1H-imidazol-2-yl)-2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione hydrochloride and acetyl chloride using triethylamine as a base. Mass: 506.09 (M+H).

Sources & evidence

ORD record
ord-639ff96acdde474f8c4f02fed1bad097
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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