Hydrochloric Acid → 3-(2-amino-5-methyl-1,3-thiazol-4-yl)-2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181789Notes

Reaction equation

HRID 1181789 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:19]([C:20]3[N:21]=[C:22]([NH:26]C(=O)OC(C)(C)C)[S:23][C:24]=3[CH3:25])=[C:18]3[C:13]([N:14]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:15](=[O:36])[N:16]([CH3:35])[C:17]3=[O:34])=[N:12]2)=[CH:2]1.Cl>O1CCOCC1>[NH2:26][C:22]1[S:23][C:24]([CH3:25])=[C:20]([C:19]2[N:11]([CH2:10][C:3]3[C:4]4[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=4[S:1][CH:2]=3)[N:12]=[C:13]3[C:18]=2[C:17](=[O:34])[N:16]([CH3:35])[C:15](=[O:36])[N:14]3[CH2:37][CH:38]([CH3:40])[CH3:39])[N:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595429tert-butyl 4-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-5-methyl-1,3-thiazol-2-ylcarbamate

Product 1

HCID 589811643-(2-amino-5-methyl-1,3-thiazol-4-yl)-2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This compound was synthesized by treating tert-butyl 4-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-5-methyl-1,3-thiazol-2-ylcarbamate with 4M HCl in dioxane at room temperature for 2.5 hours. Mass: 481.15 (M+H).

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-1acd340c24e348a0a82fbfdf4bf6cc60
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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