Trifluoroacetic acid → HCID 58981016, compound

HRID 1181807Notes

Reaction equation

HRID 1181807 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([NH:9][N:10]=[CH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[N:4]([CH2:23][CH2:24][CH3:25])[C:3]1=[O:26].C([NH:31][S:32]([C:35]1[CH:39]=[C:38]([CH:40]=O)[N:37]([CH3:42])[CH:36]=1)(=[O:34])=[O:33])(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:22][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][CH:18]=1)[N:15]=[CH:14][CH:13]=[C:12]2[CH2:11][N:10]1[C:40]([C:38]2[N:37]([CH3:42])[CH:36]=[C:35]([S:32]([NH2:31])(=[O:34])=[O:33])[CH:39]=2)=[C:6]2[C:5]([N:4]([CH2:23][CH2:24][CH3:25])[C:3](=[O:26])[N:2]([CH3:1])[C:7]2=[O:8])=[N:9]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 58980924HCID 58980924, compoundHCID 86595431HCID 86595431, compound

Product 1

HCID 58981016HCID 58981016, compound

Procedure

Following the method of Example 180, this compound was made by preparation of 6-chloroquinoline-4-carbaldehyde (1-methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone, condensation with N-(tert-butyl)-5-formyl-1-methyl-1H-pyrrole-3-sulfonamide and treatment with TFA.

Sources & evidence

ORD record
ord-63d6af9631ab4b9c930dbbb5d08e4549
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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