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HRID1181816

反应详情

EQUATION

反应方程式

HRID 1181816 的结构方程式

REACTANTS

反应物

5
结构：O=Cc1c[nH]c2ccc(Cl)cc12
HCID2795374

5-Chloroindole-3-carboxaldehyde

C9H6ClNO

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CC(=O)c1cc(C=O)n(C)c1
HCID12676268

4-Acetyl-1-methyl-1H-pyrrole-2-carbaldehyde

C8H9NO2

结构：CC(C)Cn1c(NN)cc(=O)n(C)c1=O
HCID19356084

未命名化合物

结构：CC(=O)c1cc(-c2c3c(=O)n(C)c(=O)n(CC(C)C)c3nn2Cc2c[nH]c3ccc(Cl)cc23)n(C)c1
HCID58981140

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(C)O)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21
HCID58981018

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

This compound was made in two steps following the procedure described above, starting with 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first 5-chloro-1H-indole-3-carbaldehyde, followed by 4-acetyl-1-methyl-1H-pyrrole-2-carbaldehyde. The isolated 3-(4-acetyl-1-methyl-1H-pyrrol-2-yl)-2-[(5-chloro-1H-indol-3-yl)methyl]-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione was treated sodium borohydride in anhydrous THF and heated at 80° C. for 1 h and the product was isolated by aqueous workup. The presence of alcohol peak (δ 64.8 ppm)was confirmed by 13C NMR (CDCl3)— no ketone peak at (δ 193.5 ppm).

WORKUP

后处理

  1. customthe product was isolated by aqueous workup