1-Methyl-1H-pyrrole-2-carbaldehyde → 2-(1-benzothien-3-ylmethyl)-7-isobutyl-3-(1-methyl-1H-pyrrol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181821Notes

Reaction equation

HRID 1181821 reaction equation
[NH:1]([C:3]1[N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7](=[O:13])[NH:6][C:5](=[O:14])[CH:4]=1)[NH2:2].[S:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([CH:24]=O)=[CH:16]1.[CH3:26][N:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[CH:32]=O>>[S:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([CH2:24][N:2]2[C:32]([C:28]3[N:27]([CH3:26])[CH:31]=[CH:30][CH:29]=3)=[C:4]3[C:3]([N:8]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:7](=[O:13])[NH:6][C:5]3=[O:14])=[N:1]2)=[CH:16]1

Participants

4

Reactant 3

HCID 145041-Methyl-1H-pyrrole-2-carbaldehydeHCID 2273281-Benzothiophene-3-carbaldehydeHCID 694280776-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 694271552-(1-benzothien-3-ylmethyl)-7-isobutyl-3-(1-methyl-1H-pyrrol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Procedure

This compound was isolated as a byproduct from a two step preparation as described: A): 2-(1-benzothien-3-ylmethyl)-7-isobutyl-3-(1-methyl-1H-pyrrol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione was prepared starting from 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione and condensing first with 1-benzothiophene-3-carbaldehyde, followed by 1-methyl-1H-pyrrole-2-carbaldehyde.

Workup

  1. customThis compound was isolated as a byproduct from a two step preparation

Sources & evidence

ORD record
ord-15e32caa897b44848a833d3243fdcb31
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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