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HRID1181822

反应详情

EQUATION

反应方程式

HRID 1181822 的结构方程式

REACTANTS

反应物

4
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

结构：BrCCBr
HCID7839

1,2-Dibromoethane

C2H4Br2

结构：C1CCC2=NCCCN2CC1
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：CC(C)Cn1c(=O)[nH]c(=O)c2c(-c3cccn3C)n(Cc3csc4ccccc34)nc21
HCID69427155

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)Cn1c(=O)n(CCO)c(=O)c2c(-c3cccn3C)n(Cc3csc4ccccc34)nc21
HCID58981067

未命名化合物

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

2-(1-benzothien-3-ylmethyl)-7-isobutyl-3-(1-methyl-1H-pyrrol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione was dissolved in anhydrous dimethylsulfoxide and 1,8-diazabicyclo[5.4.0]undec-7-ene was added. 1,2-dibromoethane was added and the mixture was heated at 80° C. for 18 h. The crude reaction product was purified by semi-prep RPHPLC eluting with water/acetonitrile/trifluoroacetic acid mixtures. 477 (M+H).

WORKUP

后处理

  1. customThe crude reaction product
  2. customwas purified by semi-prep RPHPLC
  3. washeluting with water/acetonitrile/trifluoroacetic acid mixtures