1-Methyl-1H-pyrrole-2-carbaldehyde → 7-(cyclopropylmethyl)-5-methyl-3-(1-methyl-1H-pyrrol-2-yl)-2-{[5-(trifluoromethyl)-1H-indol-3-yl]methyl}-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181836Notes

Reaction equation

HRID 1181836 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][NH2:12])=[CH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:3][CH2:2]1.[F:16][C:17]([F:30])([F:29])[C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[C:21]2[CH:27]=O.[CH3:31][N:32]1[CH:36]=[CH:35][CH:34]=[C:33]1[CH:37]=O>>[CH:1]1([CH2:4][N:5]2[C:10]3=[N:11][N:12]([CH2:27][C:21]4[C:20]5[C:24](=[CH:25][CH:26]=[C:18]([C:17]([F:30])([F:29])[F:16])[CH:19]=5)[NH:23][CH:22]=4)[C:37]([C:33]4[N:32]([CH3:31])[CH:36]=[CH:35][CH:34]=4)=[C:9]3[C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 145041-Methyl-1H-pyrrole-2-carbaldehydeHCID 289848795-(Trifluoromethyl)-1h-indole-3-carbaldehydeHCID 694271711-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 589809547-(cyclopropylmethyl)-5-methyl-3-(1-methyl-1H-pyrrol-2-yl)-2-{[5-(trifluoromethyl)-1H-indol-3-yl]methyl}-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Procedure

This compound was made following the procedure described above, starting with 1-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first with 5-(trifluoromethyl)-1H-indole-3-carbaldehyde, followed by 1-methyl-1H-pyrrole-2-carbaldehyde. 497.2 (M+H).

Sources & evidence

ORD record
ord-f346a423e3de4d4385558a80929cc4a2
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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