2-Methoxybenzaldehyde → (2-Methoxyphenyl)(4-methoxyphenyl)methanol

HRID 1182024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1182024
[CH:1](=[O:10])[C:2]1[C:3]([O:8][CH3:9])=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([Mg]Br)=[CH:15][CH:14]=1.[NH4+].[Cl-]>C1COCC1>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[O:8][CH3:9])[OH:10])=[CH:15][CH:14]=1

Komponenten

5

Edukt 3

HCID 86582-MethoxybenzaldehydeHCID 25517Ammonium ChlorideHCID 178491912HCID 178491912, Verbindung

Produkt 1

HCID 3811722(2-Methoxyphenyl)(4-methoxyphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1.5 g of o-anisaldehyde are dissolved in THF and cooled to 0° C. 24.2 ml of 4-methoxyphenylmagnesium bromide (0.5 M in THF) are added to the mixture. The reaction solution is stirred at room temperature overnight and then poured into a 20% NH4Cl solution and extracted with ethyl acetate. 2.63 g of the product are obtained, and this can be employed without further purification.C15H16O3 (244.29) MS (ESI+) 227.05 (M−OH)+

Aufarbeitung

  1. extractionextracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-a73e953161f34e079d4e087595bcd38b
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07288528B2

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