反应详情

2.63 g of (4-methoxyphenyl)(2-methoxyphenyl)methanol 51 are dissolved in dichloromethane, and 5.03 g of Dess-Martin reagent are added. The mixture is stirred at room temperature for 2 h. Then 20% Na2SO3 and NaHCO3 solution are added, and the mixture is extracted with diethyl ether. The organic phase is extracted with saturated NaCl solution and dried over sodium sulfate. The solution is concentrated in vacuo and purified by column filtration. 2.61 g of 52 are obtained. C15H14O3 (242.28) MS (ESI+) 243.04 (M+H+)

1. extractionthe mixture is extracted with diethyl ether
2. extractionThe organic phase is extracted with saturated NaCl solution
3. dry with materialdried over sodium sulfate
4. concentrationThe solution is concentrated in vacuo
5. filtrationpurified by column filtration