Sodium Sulfite → 2,4'-Dimethoxybenzophenone

HRID 1182025Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1182025
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[OH:10])=[CH:5][CH:4]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[O-]S([O-])=O.[Na+].[Na+].C([O-])(O)=O.[Na+]>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])=[O:10])=[CH:7][CH:8]=1

Komponenten

6

Edukt 4

HCID 24437Sodium SulfiteHCID 159087TriacetoxyperiodinaneHCID 516892Sodium BicarbonateHCID 3811722(2-Methoxyphenyl)(4-methoxyphenyl)methanol

Produkt 1

HCID 2262052,4'-DimethoxybenzophenoneAusbeute 100,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2.63 g of (4-methoxyphenyl)(2-methoxyphenyl)methanol 51 are dissolved in dichloromethane, and 5.03 g of Dess-Martin reagent are added. The mixture is stirred at room temperature for 2 h. Then 20% Na2SO3 and NaHCO3 solution are added, and the mixture is extracted with diethyl ether. The organic phase is extracted with saturated NaCl solution and dried over sodium sulfate. The solution is concentrated in vacuo and purified by column filtration. 2.61 g of 52 are obtained. C15H14O3 (242.28) MS (ESI+) 243.04 (M+H+)

Aufarbeitung

  1. extractionthe mixture is extracted with diethyl ether
  2. extractionThe organic phase is extracted with saturated NaCl solution
  3. dry with materialdried over sodium sulfate
  4. concentrationThe solution is concentrated in vacuo
  5. filtrationpurified by column filtration

Quellen und Nachweise

ORD-Eintrag
ord-d5b41e164866415f84193b15cf2b9d31
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07288528B2

Notizen zur Reaktion

Wird geladen…