HCID 58981831, compound → HCID 58981850, compound

HRID 1182063Notes

Reaction equation

HRID 1182063 reaction equation
[Br:1][C:2]1[C:3]([S:19][CH:20]([CH3:24])[C:21](=[O:23])[CH3:22])=[N:4][C:5]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:13][CH:14]=2)=[N:6][CH:7]=1.[CH3:25][Mg]Br>O1CCCC1>[Br:1][C:2]1[C:3]([S:19][CH:20]([CH3:24])[C:21]([OH:23])([CH3:25])[CH3:22])=[N:4][C:5]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:13][CH:14]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 58981831HCID 58981831, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 58981850HCID 58981850, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

108 mg (0.25 mmol) of 5-[5-bromo-4-(1-methyl-2-oxo-propylsulfanyl)-pyrimidin-2-ylamino]-pyridine-2-sulfonic acid amide is dissolved in tetrahydrofuran p.a. at 4° C. that is mixed in portions with 1 ml (3 mmol) of methylmagnesium bromide (3 M in ether). After 24 hours of stirring at room temperature, it is quenched by adding ammonium chloride solution. After extraction with ethyl acetate, the dried residue is flashed with dichloromethane/methanol.

Workup

  1. customit is quenched
  2. additionby adding ammonium chloride solution
  3. extractionAfter extraction with ethyl acetate

Sources & evidence

ORD record
ord-4fdf13d3c06d41548c65f97437003850
Source dataset
uspto-grants-2007_10
Patent number
US07288547B2

Reaction notes

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