反应详情

温度

0 °C

A solution of 5-Cyclobutyl-2-methyl-2H-pyrazol-3-ylamine (0.156 g, 1.03 mmol) in dimethylformamide (3 ml) cooled to 0° C., is treated with phenylchloroformate (0.13 ml, 1.03 mmol) dropwise and left to stir at 0° C. for 1 hour. The reaction mixture is partitioned between ethylacetate and 1.0 M hydrochloric acid solution, and the organic phase washed with water, dried over magnesium sulphate and evaporated to yield (5-Cyclobutyl-2-methyl-2H-pyrazol-3-yl)-carbamic acid phenyl ester. [M+H] 272.22

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2. customThe reaction mixture is partitioned between ethylacetate and 1.0 M hydrochloric acid solution
3. washthe organic phase washed with water
4. dry with materialdried over magnesium sulphate
5. customevaporated