Triethylamine → HCID 69423165, compound

HRID 1182246Notes

Reaction equation

HRID 1182246 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:17][CH:10]3[CH2:11][N:12]([CH:14]([CH3:16])[CH3:15])[CH2:13][CH:9]3[CH:8]2[CH2:18][O:19][CH3:20])[C:3]1=[O:21].Cl[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[C:30]([C:33]([F:36])([F:35])[F:34])[CH:31]=2)[N:26]=[CH:25][N:24]=1.C(N(CC)CC)C>C(O)C>[CH:14]([N:12]1[CH2:13][CH:9]2[CH:8]([CH2:18][O:19][CH3:20])[CH:7]([N:4]3[CH2:5][CH2:6][CH:2]([NH:1][C:23]4[C:32]5[C:27](=[CH:28][CH:29]=[C:30]([C:33]([F:35])([F:36])[F:34])[CH:31]=5)[N:26]=[CH:25][N:24]=4)[C:3]3=[O:21])[CH2:17][CH:10]2[CH2:11]1)([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 210750954-Chloro-6-(trifluoromethyl)quinazolineHCID 69426676HCID 69426676, compound

Product 1

HCID 69423165HCID 69423165, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-amino-1-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-pyrrolidin-2-one, 4-chloro-6-trifluoromethylquinazoline (see Armarego et al., J. Chem. Soc. B, 1967, 449) and triethylamine in ethanol is heated at reflux until the reaction is complete. The resulting solution is concentrated under vacuum yielding a residue. The residue is purified by reverse phase HPLC and lyophilization providing the title product.

Workup

  1. temperatureis heated
  2. temperatureat reflux until the reaction
  3. concentrationThe resulting solution is concentrated under vacuum
  4. customyielding a residue
  5. customThe residue is purified by reverse phase HPLC and lyophilization

Sources & evidence

ORD record
ord-0ec0640111e14376a82d07d3ac46ffb3
Source dataset
uspto-grants-2007_10
Patent number
US07288563B2

Reaction notes

Loading…