HCID 11372828, compound → HCID 11189454, compound

HRID 1182272Notes

Reaction equation

HRID 1182272 reaction equation
[Cl:1][C:2]1[C:7]([O:8][C:9]2[CH:10]=[C:11]([C:17]#[N:18])[CH:12]=[C:13]([CH:16]=2)[C:14]#[N:15])=[C:6]([F:19])[C:5]([CH2:20][C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[NH:23][N:22]=2)=[CH:4][CH:3]=1.ClC1C=C(C=[C:36]([O:38]C2C(Cl)=CC=C(CC3C=C(C)C(=O)NN=3)C=2F)C=1)C#N.ClC1C(OC2C=C(C=C(C(F)F)C=2)C#N)=C(F)C(CC2C=C(C)C(=O)NN=2)=CC=1>>[Cl:1][C:2]1[C:7]([O:8][C:9]2[CH:10]=[C:11]([C:17]#[N:18])[CH:12]=[C:13]([CH:16]=2)[C:14]#[N:15])=[C:6]([F:19])[C:5]([CH2:20][C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[N:23]([CH2:36][OH:38])[N:22]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11372828HCID 11372828, compoundHCID 18440025HCID 18440025, compound2×HCID 18440052HCID 18440052, compound

Product 1

HCID 11189454HCID 11189454, compound

Procedure

Compounds I-22, I-27 and I-29 can be prepared in similar manner except 5-[6-chloro-2-fluoro-3-(5-methyl-6-oxo-1,6-dihydro-pyridazin-3-ylmethyl)-phenoxy]-isophthalonitrile was replaced with 3-chloro-5-[6-chloro-2-fluoro-3-(5-methyl-6-oxo-1,6-dihydro-pyridazin-3-ylmethyl)-phenoxy]-benzonitrile, 3-[6-chloro-2-fluoro-3-(5-methyl-6-oxo-1,6-dihydro-pyridazin-3-ylmethyl)-phenoxy]-5-difluoromethyl-benzonitrile and 3-[6-chloro-2-fluoro-3-(5-methyl-6-oxo-1,6-dihydro-pyridazin-3-ylmethyl)-phenoxy]-5-difluoromethyl-benzonitrile respectively.

Sources & evidence

ORD record
ord-8d160364d9b84c40802f5387fdb2222e
Source dataset
uspto-grants-2007_10
Patent number
US07288542B2

Reaction notes

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