Thionyl Chloride → 5-(chloromethyl)-1-propyl-1H-imidazole hydrochloride

HRID 1182367ノート

反応式

HRID 1182367 の反応式
O[CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][CH:4]=1.S(Cl)([Cl:13])=O>>[ClH:13].[Cl:13][CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][CH:4]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 22938539(1-propyl-1H-imidazol-5-yl)methanol

生成物 1

HCID 229386165-(chloromethyl)-1-propyl-1H-imidazole hydrochloride

反応条件

温度
90 °C

実験手順

To 5-hydroxymethyl-1-propylimidazole (33.0 g) was portionwise added thionyl chloride (80 ml) at 0C, and the mixture was heated at 90° C. for 30 minutes under a nitrogen atmosphere. The mixture was returned to room temperature, and then the solvent was distilled off under reduced pressure. The resulting residue was dissolved in methanol, and the solvent was again distilled off under reduced pressure. The resulting solid was recrystallized from ethyl acetate to give 5-chloromethyl-1-propylimidazole hydrochloride (43.8 g) as colorless crystals.

後処理

  1. customwas returned to room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe resulting residue was dissolved in methanol
  4. distillationthe solvent was again distilled off under reduced pressure
  5. customThe resulting solid was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-3f483cbccaf5496ab85a7b9320bf3dca
出典データセット
uspto-grants-2007_10
特許番号
US07288654B2

反応ノート

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