3,3-Dimethylbutanal → Aspartame

HRID 1182393ノート

反応式

HRID 1182393 の反応式
[CH3:1][C:2]([CH2:5][CH2:6][NH:7][C@H:8]([C:13]([NH:15][C@H:16]([C:24]([O:26][CH3:27])=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:14])[CH2:9][C:10]([OH:12])=[O:11])([CH3:4])[CH3:3].S(=O)(O)[O-].CC(C)(C)CC=O>>[CH3:27][O:26][C:24]([C@@H:16]([NH:15][C:13]([C@@H:8]([NH2:7])[CH2:9][C:10]([OH:12])=[O:11])=[O:14])[CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:25].[CH3:4][C:2]([CH2:5][CH2:6][NH:7][C@H:8]([C:13]([NH:15][C@H:16]([C:24]([O:26][CH3:27])=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:14])[CH2:9][C:10]([OH:12])=[O:11])([CH3:1])[CH3:3]

参加物

5

反応物 3

HCID 763353,3-DimethylbutanalHCID 104748BisulfiteHCID 9810996Neotame

生成物 2

HCID 134601AspartameHCID 9810996Neotame

実験手順

In a second embodiment of the present invention, neotame is synthesized by first hydrolyzing a bisulfite adduct of 3,3-dimethylbutyraldehyde with a base in a solvent or a mixture of solvents and then adding aspartame under hydrogenation conditions with a catalyst to produce neotame.

後処理

  1. additiona mixture of solvents

出典と根拠

ORDレコード
ord-0685e0a65b59469ea9acb5675020bba2
出典データセット
uspto-grants-2007_10
特許番号
US07288670B2

反応ノート

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