Dansylamide → HCID 69507143, compound

HRID 1182440Notes

Reaction equation

HRID 1182440 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5](O)=[O:6].[CH3:24][N:25]([CH3:40])[C:26]1[CH:35]=[CH:34][CH:33]=[C:32]2[C:27]=1[CH:28]=[CH:29][CH:30]=[C:31]2[S:36]([NH2:39])(=[O:38])=[O:37]>>[Br:23][C:9]1[CH:8]=[C:4]([CH:3]=[C:2]([Br:1])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:21])[CH3:22])[CH:13]=1)[C:5]([C:30]1[CH:29]=[CH:28][C:27]2[C:32](=[CH:33][CH:34]=[CH:35][C:26]=2[N:25]([CH3:24])[CH3:40])[C:31]=1[S:36]([NH2:39])(=[O:38])=[O:37])=[O:6]

Participants

3

Reactant 2

HCID 65077DansylamideHCID 11015728HCID 11015728, compound

Product 1

HCID 69507143HCID 69507143, compoundYield 34.5%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 5-dimethylamino-1-naphthalenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 8 mg (34%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-4192aeb8b619495d9a03dc4ab621c01c
Source dataset
uspto-grants-2007_10
Patent number
US07288571B2

Reaction notes

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