Hydrochloric Acid → HCID 9827369, compound

HRID 1182582Notes

Reaction equation

HRID 1182582 reaction equation
[C:1]1([CH:7]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:8][CH2:9][O:10][C:11]([C:13]2[CH:14]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=3)[C:15]([C:21]([O:23]CCC#N)=[O:22])=[C:16]([CH3:20])[NH:17][C:18]=2[CH3:19])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:35]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][O:10][C:11]([C:13]2[CH:14]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=3)[C:15]([C:21]([OH:23])=[O:22])=[C:16]([CH3:20])[NH:17][C:18]=2[CH3:19])=[O:12])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69069678HCID 69069678, compound

Product 1

HCID 9827369HCID 9827369, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

808 mg (1.46 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl) ester 5-(3,3-diphenylpropyl) ester was dissolved in 15 ml of methanol. 3 ml of 1 N aqueous sodium hydroxide solution was added and stirred at room temperature for 2 hours. After adding 2 N hydrochloric acid, methanol was evaporated under reduced pressure. Water was added to the residue, and solid matters were taken by the filtration, then washed with water and hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

Workup

  1. customwas evaporated under reduced pressure
  2. additionWater was added to the residue, and solid matters
  3. filtrationwere taken by the filtration
  4. washwashed with water and hexane/ethyl acetate (3/1)
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-868f17399a6d411aa87ae199d5919b3c
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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