Acetone → HCID 10117784, compound

HRID 1182583Notes

Reaction equation

HRID 1182583 reaction equation
CC(C)=O.[C:5]1([CH:11]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:12][CH2:13][O:14][C:15]([C:17]2[CH:22]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)[C:21]([C:30]([OH:32])=[O:31])=[C:20]([CH3:33])[NH:19][C:18]=2[CH3:34])=[O:16])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[N+]([O-])([O-])=O.[NH4+].[Ce]>O>[C:35]1([CH:11]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:12][CH2:13][O:14][C:15]([C:17]2[C:18]([CH3:34])=[N:19][C:20]([CH3:33])=[C:21]([C:30]([OH:32])=[O:31])[C:22]=2[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=2)=[O:16])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 9827369HCID 9827369, compoundHCID 57418452Ammonium cerium-nitrate

Product 1

HCID 10117784HCID 10117784, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2 ml of acetone was added to 50.7 mg (0.100 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid mono (3,3-diphenylpropyl) ester. 130 mg (0.240 mmol) of cerium ammonium nitrate suspended in 1 ml of water was added and stirred at room temperature for 10 minutes. After adding water and extracting with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. extractionextracting with ethyl acetate
  3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d61cd7e67bd941c0802c1c93b953cac9
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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