Ethyl Acetate → HCID 69063286, compound

HRID 1182587Notes

Reaction equation

HRID 1182587 reaction equation
C(OCC)(=O)C.[C:7]([CH2:9][CH2:10][O:11][C:12]([C:14]1[CH:15]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=2)[C:16]([C:26]([O:28]CC2C=CC=CC=2)=[O:27])=[C:17]([CH2:21][O:22][CH2:23][CH2:24][Cl:25])[NH:18][C:19]=1[CH3:20])=[O:13])#[N:8]>[H][H].[C].[Pd]>[C:7]([CH2:9][CH2:10][O:11][C:12]([C:14]1[CH:15]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=2)[C:16]([C:26]([OH:28])=[O:27])=[C:17]([CH2:21][O:22][CH2:23][CH2:24][Cl:25])[NH:18][C:19]=1[CH3:20])=[O:13])#[N:8]

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 69074752HCID 69074752, compound

Product 1

HCID 69063286HCID 69063286, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 178418361HCID 178418361, compoundSolvent

Procedure

5 ml of ethyl acetate and 10% palladium carbon were added to 340 mg (0.640 mmol) of 2-(2-chloroethoxy) methyl-4-(3-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyanoethyl) ester. The obtained solution was stirred at room temperature in hydrogen atmosphere under normal pressure for 8 hours. After filtering the reaction mixture, the filtrate was evaporated under reduced pressure to obtain the title compound.

Workup

  1. filtrationAfter filtering the reaction mixture
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-aca2c0198f934e2e975707be9b4c47c4
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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