Hydrochloric Acid → HCID 9827369, compound

HRID 1182593Notes

Reaction equation

HRID 1182593 reaction equation
[C:1]1([CH:7]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:8][CH2:9][O:10][C:11]([C:13]2[CH:14]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=3)[C:15]([C:21]([O:23]CCC#N)=[O:22])=[C:16]([CH3:20])[NH:17][C:18]=2[CH3:19])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:35]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][O:10][C:11]([C:13]2[CH:14]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=3)[C:15]([C:21]([OH:23])=[O:22])=[C:16]([CH3:20])[NH:17][C:18]=2[CH3:19])=[O:12])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69069678HCID 69069678, compound

Product 1

HCID 9827369HCID 9827369, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

808 mg (1.46 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl) ester 5-(3,3-diphenylpropyl) ester was dissolved in 15 ml of methanol. 3 ml of 1 N aqueous sodium hydroxide solution was added and stirred at room temperature for 2 hours. After adding 2 N hydrochloric acid, methanol was evaporated under reduced pressure. Water was added thereto and the solid substance was filtered. The obtained substance was washed with water and then hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

Workup

  1. customwas evaporated under reduced pressure
  2. additionWater was added
  3. filtrationthe solid substance was filtered
  4. washThe obtained substance was washed with water
  5. dry with materialhexane/ethyl acetate (3/1) and dried under reduced pressure

Sources & evidence

ORD record
ord-4ee9b08a90d74b94b693346d8b9819ad
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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