HCID 86586138, compound → HCID 69067857, compound

HRID 1182606Notes

Reaction equation

HRID 1182606 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:28])[C:15]([C:25](=O)[CH3:26])=[CH:16][C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=2[CH3:24])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29]1([CH:35]([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[CH2:36][CH2:37][O:38][C:39](=[O:44])/[CH:40]=[C:41](\[NH2:43])/[CH3:42])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CC(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]([C:15]2[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH3:24])[C:40]([C:39]([O:38][CH2:37][CH2:36][CH:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:44])=[C:41]([CH3:42])[NH:43][C:25]=2[CH3:26])=[O:28])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 86586138HCID 86586138, compoundHCID 86619196HCID 86619196, compound

Product 1

HCID 69067857HCID 69067857, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

648 mg (1.67 mmol) of 4-[2-acetyl-3-(2,4-dimethylphenyl)-2-propenoyl]-1-piperazinecarboxylic acid t-butyl ester and 493 mg (1.67 mmol) of 3-aminocrotonate (3,3-diphenylpropyl) ester were heated and stirred in 5 ml of 2-propanol at 80° C. for two nights. After evaporating 2-propanol under reduced pressure, the residue was purified by the silica gel chromatography (hexane/ethyl acetate=5/1 to 1/9) to obtain the title compound.

Workup

  1. customAfter evaporating 2-propanol under reduced pressure
  2. customthe residue was purified by the silica gel chromatography (hexane/ethyl acetate=5/1 to 1/9)

Sources & evidence

ORD record
ord-0d2a718bc4164882afef1f923725192a
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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