Hydrochloric Acid → HCID 86590787, compound

HRID 1182621Notes

Reaction equation

HRID 1182621 reaction equation
[OH-].[Na+].[CH:3]1[C:13]2[CH:12]=[CH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]([C:30]4[CH:31]([C:45]5[CH:50]=[CH:49][CH:48]=[C:47]([Cl:51])[CH:46]=5)[C:32]([C:38]([O:40]CCC#N)=[O:39])=[C:33]([CH3:37])[NH:34][C:35]=4[CH3:36])=[O:29])[CH2:20][CH2:19]3)[C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl>CO>[CH:14]1[C:10]2[CH:11]=[CH:12][C:13]3[CH:3]=[CH:4][CH:5]=[CH:6][C:7]=3[C:8](=[C:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]([C:30]4[CH:31]([C:45]5[CH:50]=[CH:49][CH:48]=[C:47]([Cl:51])[CH:46]=5)[C:32]([C:38]([OH:40])=[O:39])=[C:33]([CH3:37])[NH:34][C:35]=4[CH3:36])=[O:29])[CH2:22][CH2:23]3)[C:9]=2[CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69069466HCID 69069466, compound

Product 1

HCID 86590787HCID 86590787, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5 ml of methanol and 0.434 ml of 1 N aqueous sodium hydroxide solution were added to 244 mg (0.36 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl) ester 5-(3-(4-(5H-dibenzo[a,d] cyclohepten-5-ylidene) piperidine-1-yl) propan-1-yl) ester and stirred at room temperature for 5 hours. After adding 1 N hydrochloric acid, precipitates were taken by the filtration and dried under reduced pressure to obtain the title compound.

Workup

  1. customprecipitates
  2. filtrationwere taken by the filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-36b6a8f8c73d478a8883bd4d670d8c2d
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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