2-Phenyl-4-carboxythiazole → 4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester

HRID 1182679Notes

Reaction equation

HRID 1182679 reaction equation
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21])[CH2:16][CH2:17][CH3:18]>>[CH2:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:12](=[O:14])[CH2:10][NH:11][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[S:8][CH:9]=2)=[O:14])[CH2:24][CH2:23]1)=[O:21])[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 1389282-Phenyl-4-carboxythiazoleHCID 21963126Butyl piperazine-1-carboxylate

Product 1

HCID 497645624-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester

Procedure

This compound was prepared using a method analogous to that of Example 3, step 3.2, 2-phenyl-1.3-thiazole-4-carboxylic acid replacing intermediate 3.1 and intermediate 26.2 replacing piperazine-1-carboxylic acid butyl ester.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-75242c61677f49de9bba78213b0c898f
Source dataset
uspto-grants-2014_03
Patent number
US08664203B2

Reaction notes

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