2-Phenyl-4-carboxythiazole → HCID 49764818, compound

HRID 1182680Notes

Reaction equation

HRID 1182680 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:20])[C@@H:15]([NH2:19])[CH:16]([CH3:18])[CH3:17])[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].[C:21]1([C:27]2[S:28][CH:29]=[C:30]([C:32](O)=[O:33])[N:31]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)Cl>[CH2:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:20])[C@@H:15]([NH:19][C:32]([C:30]2[N:31]=[C:27]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[S:28][CH:29]=2)=[O:33])[CH:16]([CH3:17])[CH3:18])[CH2:12][CH2:13]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 1389282-Phenyl-4-carboxythiazoleHCID 66651993HCID 66651993, compound

Product 1

HCID 49764818HCID 49764818, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared using a method analogous to that of Example 8, step 8.3, 4-((S)-2-amino-3-methyl-butyryl)-piperazine-1-carboxylic acid butyl ester (prepared as described in WO2008044217) replacing piperazine-1-carboxylic acid butyl ester, phenyl-1,3-thiazole-4-carboxylic acid replacing intermediate 8.2 and using CH2Cl2 instead of CH2Cl2/THF. The compound was however purified by CC (EtOAc/Hept 0:1 to EtOAc/Hept 1:0).

Workup

  1. customThis compound was prepared
  2. customThe compound was however purified by CC (EtOAc/Hept 0:1 to EtOAc/Hept 1:0)

Sources & evidence

ORD record
ord-e5b747c3e0a44d2a8315ea3c1e555ae6
Source dataset
uspto-grants-2014_03
Patent number
US08664203B2

Reaction notes

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