Hydrochloric Acid → HCID 66778091, compound

HRID 1182681Notes

Reaction equation

HRID 1182681 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C@@H:15]([NH:18]C(OC(C)(C)C)=O)[CH2:16][OH:17])[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].[ClH:27]>C(Cl)Cl.CCOCC>[ClH:27].[CH2:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:26])[CH:15]([NH2:18])[CH2:16][OH:17])[CH2:12][CH2:13]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66651693HCID 66651693, compound

Product 1

HCID 66778091HCID 66778091, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

Workup

  1. filtrationthe white cake was filtered
  2. washwashed with Et2O
  3. customdried at HV overnight
  4. customThe crude (1.19 g) was used without purification

Sources & evidence

ORD record
ord-7b82b37af85e4cf198d284c9a811bfe8
Source dataset
uspto-grants-2014_03
Patent number
US08664203B2

Reaction notes

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