HCID 45140546, compound → 4-{(S)-2-[(5-Bromo-4-phenyl-thiazole-2-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid butyl ester

HRID 1182682Notes

Reaction equation

HRID 1182682 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[N:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH2:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([C:29](=[O:41])[C@@H:30]([NH2:40])[CH2:31][CH2:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:25][CH2:24]1)=[O:22])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([C:29](=[O:41])[C@@H:30]([NH:40][C:7]([C:5]2[S:6][C:2]([Br:1])=[C:3]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:4]=2)=[O:9])[CH2:31][CH2:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:25][CH2:24]1)=[O:22])[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 45140546HCID 45140546, compoundHCID 667701215-Bromo-4-phenylthiazole-2-carboxylic acid

Product 1

HCID 667718074-{(S)-2-[(5-Bromo-4-phenyl-thiazole-2-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid butyl ester

Procedure

This compound was prepared using a method analogous to that of Example 8, step 8.5, intermediate 48.3 replacing 5-bromo-4-phenyl-thiazole-2-carboxylic acid and (S)-4-(2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester replacing intermediate 8.4.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0e0040061bf441e9a8a07973c85a197f
Source dataset
uspto-grants-2014_03
Patent number
US08664203B2

Reaction notes

Loading…