HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate → 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate | HCID 71285609 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane | HCID 71285267 | — |
Reaction Steps
tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, crude 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane, was used in the further reactions without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664213B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-ce7439d7c9f74eac9e62ec5b34a72fc9 |
| Source note | uspto-grants-2014_03 |