tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate → 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane

HRID 1182686Notes

Reaction equation

HRID 1182686 reaction equation
[C:1]1([N:7]2[C:11]([N:12]3[CH2:27][CH2:26][C:14]4([CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]4)[CH2:13]3)=[N:10][N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:1]1([N:7]2[C:11]([N:12]3[CH2:27][CH2:26][C:14]4([CH2:15][CH2:16][NH:17][CH2:18]4)[CH2:13]3)=[N:10][N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 71285609tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

Product 1

HCID 712852672-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, crude 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane, was used in the further reactions without purification.

Workup

  1. customAfter removal of solvents
  2. customthe residue, crude 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane, was used in the further reactions without purification

Sources & evidence

ORD record
ord-ce7439d7c9f74eac9e62ec5b34a72fc9
Source dataset
uspto-grants-2014_03
Patent number
US08664213B2

Reaction notes

Loading…