HCID 71282812, compound → HCID 71282710, compound

HRID 1182688Notes

Reaction equation

HRID 1182688 reaction equation
[C:1]([N:9]1[CH2:24][CH2:23][C:11]2([CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:2]1([C:1]([N:9]2[CH2:24][CH2:23][C:11]3([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)=[O:8])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 71282812HCID 71282812, compound

Product 1

HCID 71282710HCID 71282710, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone, was used in the further reactions without purification.

Workup

  1. customAfter removal of solvents
  2. customthe residue, phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone, was used in the further reactions without purification

Sources & evidence

ORD record
ord-e167651553d349bcbe2ded3bd9855947
Source dataset
uspto-grants-2014_03
Patent number
US08664213B2

Reaction notes

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