反应详情

5 g (15.8 mmol) 7-bromo-2,4-dichloro-5H-pyrimido[5,4-b]indole was suspended in 20 ml ethanol and mixed with 15.8 ml (31.5 mmol) 2M sodium ethylate solution (EtOH). The mixture was refluxed for 9.5 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 5.1 g (99%) 7-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole was obtained. ESI-MS [m/z]: 324, 326 [M−H]−

1. temperatureThe mixture was refluxed for 9.5 h
2. concentrationthe solvent was concentrated
3. additionwater was added
4. washwashed with water