Piperazine → HCID 66863396, compound

Participants

Reaction Steps

0.8 g (2.4 mmol) 6-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole and 0.8 g (9.3 mmol) piperazine were refluxed in 10 ml mesitylene for 2.5 h. Then, the solvent was removed and the residue was suspended in water and sucked off. 0.8 g (85%) 6-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole was obtained. ESI-MS [m/z]: 376, 378 [M+H]+

Provenance & Evidence