Piperazine → HCID 66863396, compound

HRID 1182853Notes

Reaction equation

HRID 1182853 reaction equation
[Br:1][C:2]1[C:10]2[NH:9][C:8]3[C:11]([O:16][CH2:17][CH3:18])=[N:12][C:13](Cl)=[N:14][C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1(C)C=C(C)C=C(C)C=1>[Br:1][C:2]1[C:10]2[NH:9][C:8]3[C:11]([O:16][CH2:17][CH3:18])=[N:12][C:13]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)=[N:14][C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 58118559HCID 58118559, compound

Product 1

HCID 66863396HCID 66863396, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 7947MesityleneSolvent

Procedure

0.8 g (2.4 mmol) 6-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole and 0.8 g (9.3 mmol) piperazine were refluxed in 10 ml mesitylene for 2.5 h. Then, the solvent was removed and the residue was suspended in water and sucked off. 0.8 g (85%) 6-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole was obtained. ESI-MS [m/z]: 376, 378 [M+H]+

Workup

  1. customThen, the solvent was removed

Sources & evidence

ORD record
ord-f24dcc0cefa745e4aa0d18ab3f877e92
Source dataset
uspto-grants-2014_03
Patent number
US08664233B2

Reaction notes

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