HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → 7-bromo-4-ethoxy-2-(4-piperidyl)-5H-pyrimido[5,4-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 7-bromo-4-chloro-2-(4-piperidyl)-5H-pyrimido[5,4-b]indole | HCID 86650199 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-bromo-4-ethoxy-2-(4-piperidyl)-5H-pyrimido[5,4-b]indole | HCID 66863542 | — |
Reaction Steps
300 mg (0.82 mmol) 7-bromo-4-chloro-2-(4-piperidyl)-5H-pyrimido[5,4-b]indole was mixed with an excess of 2 M NaOEt and kept at reflux for 2 h. Then, water was added and the solvent was removed in vacuo. Following LC (CH2Cl2/MeOH, 0-50%), 160 mg (52%) of the title substance was obtained ESI-MS [m/z]: 375, 377 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664233B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-245c04e82887444ba9e66b8a2ef82225 |
| Source note | uspto-grants-2014_03 |