4-Piperidyloxyamine dihydrochloride → HCID 87573665, compound

HRID 1182863Notes

Reaction equation

HRID 1182863 reaction equation
[CH3:1][C:2]1([CH3:26])[C:19](=O)[CH2:18][CH2:17][C@@:16]2([CH3:21])[CH:3]1[C@@H:4]([CH2:24][OH:25])[C@@H:5]([OH:23])[C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C@@H:10]2[OH:22].[ClH:27].Cl.[NH:29]1[CH2:34][CH2:33][CH:32]([O:35][NH2:36])[CH2:31][CH2:30]1>N1C=CC=CC=1>[ClH:27].[NH:29]1[CH2:34][CH2:33][CH:32]([O:35]/[N:36]=[C:19]2/[C:2]([CH3:26])([CH3:1])[CH:3]3[C@:16]([CH3:21])([CH2:17][CH2:18]/2)[C@@H:15]2[C@H:6]([C@H:7]4[C@@:11]([CH2:13][CH2:14]2)([CH3:12])[C@@H:10]([OH:22])[CH2:9][CH2:8]4)[C@H:5]([OH:23])[C@@H:4]3[CH2:24][OH:25])[CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 103134494-Piperidyloxyamine dihydrochlorideHCID 687308144,4-Dimethyl-6alpha-hydroxymethyl-7alpha,17beta-dihydroxyandrostan-3-one

Product 1

HCID 87573665HCID 87573665, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4,4-Dimethyl-6α-hydroxymethyl-7α,17β-dihydroxyandrostan-3-one (Preparation 10, 40 mg) and 4-piperidyloxyamine dihydrochloride (Preparation 16, 52 mg) were dissolved in pyridine (1.0 ml) and stirred at RT for 4 days. After evaporation of the solvent, the resulting solid was triturated with DCM/AcOEt 1/1 to give, after filtration, the title compound (40 mg, 86%).

Workup

  1. customAfter evaporation of the solvent
  2. customthe resulting solid was triturated with DCM/AcOEt 1/1
  3. customto give
  4. filtrationafter filtration

Sources & evidence

ORD record
ord-dcd5da7b271d47d58976b96fffa7d379
Source dataset
uspto-grants-2014_03
Patent number
US08664210B2

Reaction notes

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