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HRID1182863

反应详情

EQUATION

反应方程式

HRID 1182863 的结构方程式

REACTANTS

反应物

2
结构：Cl.Cl.NOC1CCNCC1
HCID10313449

未命名化合物

结构：CC1(C)C(=O)CC[C@@]2(C)C1[C@@H](CO)[C@@H](O)[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12
HCID68730814

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)/C(=N/OC2CCNCC2)CC[C@@]2(C)C1[C@@H](CO)[C@@H](O)[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12.Cl
HCID87573665

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

4,4-Dimethyl-6α-hydroxymethyl-7α,17β-dihydroxyandrostan-3-one (Preparation 10, 40 mg) and 4-piperidyloxyamine dihydrochloride (Preparation 16, 52 mg) were dissolved in pyridine (1.0 ml) and stirred at RT for 4 days. After evaporation of the solvent, the resulting solid was triturated with DCM/AcOEt 1/1 to give, after filtration, the title compound (40 mg, 86%).

WORKUP

后处理

  1. customAfter evaporation of the solvent
  2. customthe resulting solid was triturated with DCM/AcOEt 1/1
  3. customto give
  4. filtrationafter filtration