HuagongsheHuagongshe Chemistry Print Report · For research reference only
3(R)-Pyrrolidinyloxyamine dihydrochloride → (3E,5S,8S,9S,10R,13S,14S,17S)-4,4,10,13-tetramethyl-3-[(3R)-pyrrolidin-3-yl]oxyimino-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-5,17-diol;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3(R)-Pyrrolidinyloxyamine dihydrochloride | HCID 66713918 | — |
| Reactant | 4,4-Dimethyl-5alpha,17beta-dihydroxyandrostan-3-one | HCID 68729176 | — |
| Product | (3E,5S,8S,9S,10R,13S,14S,17S)-4,4,10,13-tetramethyl-3-[(3R)-pyrrolidin-3-yl]oxyimino-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-5,17-diol;hydrochloride | HCID 87573863 | — |
Reaction Steps
The title compound was obtained in 51% yield following the procedure described in Example 2 and starting from 4,4-dimethyl-5α,17β-dihydroxyandrostan-3-one (Preparation 28, 33 mg) and 3-(R)-pyrrolidinyloxyamine dihydrochloride (Preparation 12, 69 mg). The crude product was triturated with Et2O and the resulting precipitate was filtered to give the title compound I-by.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664210B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-4617611e812f4a1aafdfd6b557fc366f |
| Source note | uspto-grants-2014_03 |