huagongshe.com
HRID1182880

反应详情

EQUATION

反应方程式

HRID 1182880 的结构方程式

REACTANTS

反应物

4
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：CCC1=C2[C@H](O)C[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
HCID68732269

未命名化合物

结构：CCC1=C2[C@@H](O)C[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
HCID68733032

未命名化合物

结构：CC(C)=O.O=S(=O)(O)O.[O]=[Cr](=[O])=[O]
HCID131709961

未命名化合物

PRODUCTS

生成物

1
结构：CCC1=C2C(=O)C[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
HCID68730766

未命名化合物

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

To a solution of a 6α-hydroxy-17β-acetoxy-4-ethylandrost-4-en-3-one and 6β-hydroxy-17β-acetoxy-4-ethylandrost-4-en-3-one (510 mg) in acetone (34 ml) cooled at 0° C., Jones reagent (1.1 ml) was added dropwise. 5 min after completion of the addition, DCM (140 ml) was added and the mixture was washed with 10% Na2SO3 aqueous solution, 5% aqueous NaHCO3 solution, and brine. The organic phase was dried over Na2SO4, and evaporated to dryness to give 17β-acetoxy-4-ethylandrost-4-en-3,6-dione (465 g, 92%).

WORKUP

后处理

  1. additionwas added
  2. washthe mixture was washed with 10% Na2SO3 aqueous solution, 5% aqueous NaHCO3 solution, and brine
  3. dry with materialThe organic phase was dried over Na2SO4
  4. customevaporated to dryness