HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-3-pyrrolidinyloxyamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (S)-3-(aminooxy)pyrrolidine-1-carboxylate | HCID 59596622 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-3-pyrrolidinyloxyamine dihydrochloride | HCID 68728672 | 73% |
Reaction Steps
(S)-1-tert-Butoxycarbonyl-3-pyrrolidinyloxyamine (1.67 g) was dissolved in a 5M HCl solution in EtOAc (20 ml). After 1 h the solvent was removed under reduced pressure to give (S)-3-pyrrolidinyloxyamine dihydrochloride (1.04 g, 73%) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664210B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-35385a8623954518b105a35237cf0d91 |
| Source note | uspto-grants-2014_03 |