Trifluoroacetic acid → HCID 57499098, compound

HRID 1182905Notes

Reaction equation

HRID 1182905 reaction equation
[CH3:1][O:2][C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:13](=[O:46])[CH2:14][N:15]2[C:24](=[O:25])[C:23]3[N:22]([CH2:26][CH:27]=[C:28]([CH3:30])[CH3:29])[C:21]([N:31]4[CH2:36][CH2:35][CH2:34][CH:33]([NH:37]C(OC(C)(C)C)=O)[CH2:32]4)=[N:20][C:19]=3[N:18]([CH3:45])[C:16]2=[O:17])[CH:10]=[CH:11][CH:12]=1)=[O:4].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:13](=[O:46])[CH2:14][N:15]2[C:24](=[O:25])[C:23]3[N:22]([CH2:26][CH:27]=[C:28]([CH3:30])[CH3:29])[C:21]([N:31]4[CH2:36][CH2:35][CH2:34][CH:33]([NH2:37])[CH2:32]4)=[N:20][C:19]=3[N:18]([CH3:45])[C:16]2=[O:17])[CH:10]=[CH:11][CH:12]=1)=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66724237HCID 66724237, compound

Product 1

HCID 57499098HCID 57499098, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared by treating 1-(2-{3-[(methoxycarbonyl)methoxy]-phenyl}-2-oxo-ethyl)-3-methyl-7-(3-methyl-2-buten-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine with trifluoroacetic acid in methylene chloride at ambient temperature.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6749b2de8d4043ccac451b89d90ec8ff
Source dataset
uspto-grants-2014_03
Patent number
US08664232B2

Reaction notes

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