Hydrogen Bromide → HCID 25145376, compound

HRID 1182984Notes

Reaction equation

HRID 1182984 reaction equation
[Cl:1][C:2]1[C:11]2[C:10]([S:12]([N:15]3[CH2:19][CH2:18][C@H:17]([NH:20][CH3:21])[CH2:16]3)(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[BrH:22]>C(O)C>[BrH:22].[Cl:1][C:2]1[C:11]2[C:10]([S:12]([N:15]3[CH2:19][CH2:18][C@H:17]([NH:20][CH3:21])[CH2:16]3)(=[O:13])=[O:14])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 25113700HCID 25113700, compound

Product 1

HCID 25145376HCID 25145376, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

(S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine (100 mg) obtained in Example 1 was dissolved in ethanol (2.5 ml), and added with 48% hydrobromic acid (33.2 μL, Wako Pure Chemical Industries), and the mixture was stirred at room temperature for 17 hours. The reaction mixture was further added with ethanol (4 ml), and the deposited solid was collected by filtration and dried by warming at 60° C. for 24 hours under reduced pressure to obtain the title compound (93.5 mg).

Workup

  1. filtrationthe deposited solid was collected by filtration
  2. customdried
  3. temperatureby warming at 60° C. for 24 hours under reduced pressure

Sources & evidence

ORD record
ord-06ac34a1e13445b18582dc8b48895af5
Source dataset
uspto-grants-2014_03
Patent number
US08664243B2

Reaction notes

Loading…