反应详情

2-(Cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (318 mg, 0.756 mmol) was dissolved in methanol (3 mL). Fumaric acid solution (29 mg/3 mL, 2.1 equivalents) was added. The mixture was dried at room temperature under vacuum. The recovered solid was dissolved in isopropanol (1 mL). One milliliter of ethyl acetate was added and the solution was placed in refrigerator. The solids were collected by vacuum filtration.

1. customThe mixture was dried at room temperature under vacuum
2. dissolutionThe recovered solid was dissolved in isopropanol (1 mL)
3. additionOne milliliter of ethyl acetate was added
4. filtrationThe solids were collected by vacuum filtration