Fumaric Acid → 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide difumarate monohydrate

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Reaction Steps

2-(Cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (318 mg, 0.756 mmol) was dissolved in methanol (3 mL). Fumaric acid solution (29 mg/3 mL, 2.1 equivalents) was added. The mixture was dried at room temperature under vacuum. The recovered solid was dissolved in isopropanol (1 mL). One milliliter of ethyl acetate was added and the solution was placed in refrigerator. The solids were collected by vacuum filtration.

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