反应详情

温度

140 °C

1.0 g (4.99 mmol) of tert-butyl 3-aminopiperidine-1-carboxylate and 1.383 g (9.99 mmol) of 6-chloropyridine-3-carbonitrile and 1.29 g (9.99 mmol) of diisopropylethylamine were suspended in 40 ml of DMSO and heated to 140° C. in a microwave reactor for 45 min. The mixture was substantially freed of the DMSO by Kugelrohr distillation and admixed with water, and the precipitating solid was filtered off. After drying under high vacuum, 2.24 g (46% of theory) of the product were obtained.

1. distillationThe mixture was substantially freed of the DMSO by Kugelrohr distillation
2. filtrationthe precipitating solid was filtered off
3. customAfter drying under high vacuum, 2.24 g (46% of theory) of the product
4. customwere obtained